Amino Acids, Peptides and Proteins in Organic Chemistry, by Andrew B. Hughes

By Andrew B. Hughes

This is the second one of 5 books within the Amino Acids, Peptides and Proteins in natural Synthesis series. 

Closing a spot within the literature, this can be the one sequence to hide this significant subject in natural and biochemistry. Drawing upon the mixed services of the foreign "who's who" in amino acid study, those volumes signify a true benchmark for amino acid chemistry, supplying a finished dialogue of the incidence, makes use of and purposes of amino acids and, via extension, their polymeric kinds, peptides and proteins.

The sensible price of every quantity is heightened by means of the inclusion of experimental procedures.


The five volumes conceal the next topics:

Volume 1: Origins and Synthesis of Amino Acids

Volume 2: transformed Amino Acids, Organocatalysis and Enzymes

Volume three: construction Blocks, Catalysis and Coupling Chemistry

Volume four: safeguard Reactions, Medicinal Chemistry, Combinatorial Synthesis

Volume five: research and serve as of Amino Acids and Peptides


Clearly dependent in 3 major sections, this moment quantity within the sequence starts off with the synthesis and chemistry of changed amino acids. the second one half bargains with the catalysis of reactions through amino acids, whereas the ultimate part is dedicated to enzymes, together with proteases as catalysts, semisynthetic enzymes, catalysis via peptide-based enzyme versions, substrate and protein popularity, in addition to mammalian and bug peptide hormones.


Originally deliberate as a six quantity sequence, Amino Acids, Peptides and Proteins in natural Chemistry now completes with 5 volumes yet is still accomplished in either scope and coverage.

Further information regarding the five quantity Set and buying info could be seen here.

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Additional info for Amino Acids, Peptides and Proteins in Organic Chemistry, Modified Amino Acids, Organocatalysis and Enzymes (Amino Acids, Peptides and Proteins in Organic Chemistry (VCH)) (Volume 2)

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And Beisswenger, T. (1984) Chemische Berichte, 117, 1497–1512. , K€ uhlwein, J. and Ziegler, T. (1988) Synthesis, 218–219. 38 Erlenmeyer, E. (1900) Ber, 33, 2036–2041. 39 (a) Gaset, A. P. A. and Melendez, E. (1983) Synthesis, 899–902. K. K. (1985) Synthesis, 285–288. K. and Kumar, P. G. (1992) Tetrahedron, 48, 177–186. S. (1981) Monatshefte fur Chemie, 112, 369–383. , K€onig, W. and Weygand, F. (1968) Chemische Berichte, 101, 308–322. , Lindsey, J. H. (1982) The Journal of Organic Chemistry, 47, 4029–4032.

If the cuprate is generated in situ from a halide via halogen–zinc exchange (Luche conjugate addition) [116] the reaction can be carried out under aqueous conditions [117]. The addition of sulfur ylides to DDAAs is a straightforward approach to 1aminocyclopropane carboxylic acids [118]. Williams et al. 23). Excellent yields and diastereoselectivities were obtained, and the free amino acid was obtained via reduction under Birch conditions and subsequent cleavage of the Boc protecting group [55, 119].

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