Amino Acids, Peptides and Proteins in Organic Chemistry, by Andrew B. Hughes

By Andrew B. Hughes

This is the 3rd of 5 books within the Amino Acids, Peptides and Proteins in natural Synthesis series. 

Closing a spot within the literature, this can be the one sequence to hide this crucial subject in natural and biochemistry. Drawing upon the mixed services of the foreign "who's who" in amino acid learn, those volumes characterize a true benchmark for amino acid chemistry, supplying a entire dialogue of the incidence, makes use of and functions of amino acids and, by way of extension, their polymeric varieties, peptides and proteins.

The sensible worth of every quantity is heightened by way of the inclusion of experimental procedures.


The five volumes conceal the next topics:

Volume 1: Origins and Synthesis of Amino Acids

Volume 2: transformed Amino Acids, Organocatalysis and Enzymes

Volume three: development Blocks, Catalysis and Coupling Chemistry

Volume four: safety Reactions, Medicinal Chemistry, Combinatorial Synthesis

Volume five: research and serve as of Amino Acids and Peptides


This 3rd quantity within the sequence provides a close account of contemporary advancements within the (bio-)synthesis of amino acids and peptides. Divided into elements, the 1st part bargains with amino acids as construction blocks, together with the iteration of alpha-amino acids, beta-lactams, and heterocycles. the second one part is dedicated to the synthesis of peptides, with the point of interest on reliable section synthesis. even though, answer section peptide synthesis is roofed in addition, as are issues similar to coupling reagents, chemical ligation, peptide purification and automation.


Originally deliberate as a six quantity sequence, Amino Acids, Peptides and Proteins in natural Chemistry now completes with 5 volumes yet continues to be finished in either scope and coverage.

Further information regarding the five quantity Set and buying information should be considered here.

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Additional resources for Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry (Amino Acids, Peptides and Proteins in Organic Chemistry (VCH)) (Volume 3)

Example text

Subsequently, in other bacteria, a different family of smaller DITTOs were identified; these are sometimes fused to a second domain catalyzing the last step of arginine biosynthesis, argininosuccinate lyase – a hint of higher-level order in the biosynthetic apparatus. Other bacteria use a completely different enzyme for the acetylation chemistry: an ornithine acetyltransferase [138]. This enzyme acts via a sequential Bi Bi kinetic mechanism whereby it accepts an acetyl group from ornithine onto an active-site threonine, generating an acetyl-enzyme intermediate, and then, in a second step, transfers it to glutamate [139].

Valine and isoleucine are made from precursor a-keto acids by a common route, which also provides a key biosynthetic precursor for leucine. The carbon skeleton of leucine is made from an a-keto acid intermediate in valine biosynthesis by a pathway homologous to the biosynthesis of a-KG in the TCA cycle. This route, in turn is utilized for the biosynthesis of another amino acid, a-aminoadipic acid, which is not incorporated into proteins but is a biosynthetic precursor to lysine in one of the pathways to that amino acid.

These findings, in turn, have led to developments in our understanding of the biosynthesis of selenocysteine in humans [67]. This area presents a nice case study in the emerging use of genome analysis to identify new variants in biosynthetic pathways. 1 Cysteine Biosynthesis in Mycobacterium Tuberculosis Amino acid biosynthesis in Mycobacterium tuberculosis is under active investigation because of the growing health threat posed by tuberculosis. Inhibitors of distinctive essential metabolic pathways in this organism may be useful as antibiotics.

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